CAS Number:*********3

Category Number: HY**1M1

Biological Source: Oryza Sativa (Rice Grain)

Physical Appearance:  Lyophilized Powder

Synonyms:

bFGF, Fibroblast Growth Factor-basic, FGF*2, FGF-β,HBGF*2,Prostatropin

Introduction:

Basic fibroblast growth factor (bFGF) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro.

Application:

1. Medicine and clinical research:

It is considered to function in several important physiological and pathological processes, such as embryonic development, morphogenesis, angiogenesis, wound healing and atheromatosis, carcinogenesis, development, and invasion of cancer.

2. Cell culture research:

bFGF is required for the maintenance of human embryonic stem cells in culture, and various other stem cell lines such as mesenchymal stem (stroma) cells (MSC).

bFGF is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. It has been demonstrated to inducegremlin expression which in turn is known to inhibit the induction of differentiation bybone morphogenetic proteins. It is also necessary in mouse-feeder cell dependent culture systems, as well as in feeder and serum-free culture systems.

3. Cosmetic raw material:

a) Cosmetics for wrinkle repair and improvement of skin functions. 

It acts as the factor to keep the acid balance in and out of the skin, restore the aged tissues and cares the wound. Thus, it is essential element for keeping the body to the optimal conditions.
b) Restoration to the normal skin after peeling for the cosmetic purpose. 

c) Acceleration of hair growth. 

It accelerates the hair growth by improving the synthesis of Collagen and Elastin. It also inhibits the discoloration of hair. In addition, it improves the skin resilience and repairs wrinkle. 

Usage:

For Research, Laboratory and Manufacture Use. The product should not be used as drugs and food additives.

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